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Metabonomics-Based Study of Clinical Urine Samples in Suboptimal Health with Different Syndromes
Joint Authors
Jiang, You-Ming
Cui, Hai-Zhen
Wang, Li-Min
Li, Xiao-Hong
Wang, Shao-Xian
Zhao, Xin
Liu, Yue-Yun
Chen, Jia-Xu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To explore the urinary biochemistry features of syndromes of traditional Chinese medicine (TCM) such as syndrome of stagnation of liver Qi, spleen deficiency, liver Qi stagnation, and spleen deficiency (LSSDS) in sub-optimal health status (SHS).
Methods.
12 cases for each syndrome group in SHS were selected, 12 subjects were used as a normal control group, and 1H NMR detection was, respectively, carried out, and the data was corrected by the orthogonal signal correction (OSC) and then adopted a partial least squares (PLS) method for discriminate analysis.
Results.
The OSC-PLS (ctr) analysis results of the nuclear overhauser enhancement spectroscopy (NOESY) detection indicated that the syndromes in SHS could be differentiated, and there were significant differences in the levels of metabolites of the urine samples of the four groups; the biomarkers of LSSDS in SHS were found out.
The contents of citric acid (2.54 and 2.66), trimethylamineoxide (3.26), and hippuric acid (3.98, 7.54, 7.58, 7.62, 7.66, 7.82, and 7.86) in the urine samples of LSSDS group were lower than that of the normal control group.
Conclusion.
There are differences in the 1H-NMR metabolic spectrum of the urine samples of the four groups, and the specific metabolic products of the LSSDS in SHS can be identified from metabonomics analysis.
American Psychological Association (APA)
Cui, Hai-Zhen& Wang, Li-Min& Zhao, Xin& Liu, Yue-Yun& Wang, Shao-Xian& Li, Xiao-Hong…[et al.]. 2013. Metabonomics-Based Study of Clinical Urine Samples in Suboptimal Health with Different Syndromes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477284
Modern Language Association (MLA)
Cui, Hai-Zhen…[et al.]. Metabonomics-Based Study of Clinical Urine Samples in Suboptimal Health with Different Syndromes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-477284
American Medical Association (AMA)
Cui, Hai-Zhen& Wang, Li-Min& Zhao, Xin& Liu, Yue-Yun& Wang, Shao-Xian& Li, Xiao-Hong…[et al.]. Metabonomics-Based Study of Clinical Urine Samples in Suboptimal Health with Different Syndromes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477284