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FSim : A Novel Functional Similarity Search Algorithm and Tool for Discovering Functionally Related Gene Products
Joint Authors
Zhang, ZhengGuo
Hu, Qiang
Wang, ZhiGang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
During the analysis of genomics data, it is often required to quantify the functional similarity of genes and their products based on the annotation information from gene ontology (GO) with hierarchical structure.
A flexible and user-friendly way to estimate the functional similarity of genes utilizing GO annotation is therefore highly desired.
Results.
We proposed a novel algorithm using a level coefficient-weighted model to measure the functional similarity of gene products based on multiple ontologies of hierarchical GO annotations.
The performance of our algorithm was evaluated and found to be superior to the other tested methods.
We implemented the proposed algorithm in a software package, FSim, based on R statistical and computing environment.
It can be used to discover functionally related genes for a given gene, group of genes, or set of function terms.
Conclusions.
FSim is a flexible tool to analyze functional gene groups based on the GO annotation databases.
American Psychological Association (APA)
Hu, Qiang& Wang, ZhiGang& Zhang, ZhengGuo. 2014. FSim : A Novel Functional Similarity Search Algorithm and Tool for Discovering Functionally Related Gene Products. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477286
Modern Language Association (MLA)
Hu, Qiang…[et al.]. FSim : A Novel Functional Similarity Search Algorithm and Tool for Discovering Functionally Related Gene Products. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-477286
American Medical Association (AMA)
Hu, Qiang& Wang, ZhiGang& Zhang, ZhengGuo. FSim : A Novel Functional Similarity Search Algorithm and Tool for Discovering Functionally Related Gene Products. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477286