Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation
Joint Authors
Georgas, Evangelos
Otto, Stephan
Gerullis, Holger
Barski, Dimitri
Ysebaert, Dirk
Otto, Thomas
Eimer, Christoph
Ramon, Albert
Klosterhalfen, Bernd
Borós, Mihaly
Arndt, Christian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model.
Materials and Methods.
Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep.
Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay).
At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation.
The results were related to long-term values over 24 months.
Results.
Macrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%.
Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up.
For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min.
Conclusion.
The local inflammatory reaction is an early and susceptible event after mesh implantation.
It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.
American Psychological Association (APA)
Gerullis, Holger& Georgas, Evangelos& Borós, Mihaly& Klosterhalfen, Bernd& Eimer, Christoph& Arndt, Christian…[et al.]. 2014. Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477445
Modern Language Association (MLA)
Gerullis, Holger…[et al.]. Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-477445
American Medical Association (AMA)
Gerullis, Holger& Georgas, Evangelos& Borós, Mihaly& Klosterhalfen, Bernd& Eimer, Christoph& Arndt, Christian…[et al.]. Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477445