New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions : Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium
Joint Authors
Song, Xueqing
Sulaxna,
Nath, Mala
Eng, George
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Di- and triorganotin(IV) derivatives of tyrosylalanine (H2Tyr-Ala) with general formula R2Sn(Tyr-Ala) (where R = Me, n-Bu, n-Oct, and Ph) and R3Sn(HTyr-Ala) (where R = Me and Ph) have been synthesized and structurally characterized in the solid state as well as in solution on the basis of various spectroscopic techniques, namely.
FT-IR, multinuclear (1H, 13C and 119Sn) NMR and 119Sn Mössbauer.
These investigations suggest that tyrosylalanine in R2Sn(Tyr-Ala) acts as dianionic tridentate ligand coordinating through carboxylate oxygen [–C(O)O−], amino (–NH2), and (CO)Npeptide- nitrogen, while in the case of R3Sn(HTyr-Ala), the ligand acts as monoanionic bidentate coordinating through –C(O)O− and –NH2, and the polyhedron around tin in R2Sn(Tyr-Ala) and R3Sn(HTyr-Ala) is a distorted trigonal-bipyramidal.
Equilibrium (pH-metric) studies of the interaction of Me2Sn(IV)2+ and Me3Sn(IV)+ with dipeptides namely, tyrosylalanine (H2Tyr-Ala), glycyltyrosine (H2Gly-Tyr), and glycylisoleucine (H2Gly-Ile), in aqueous solution (I = 0.1 M KNO3, 298 K) have also been carried out.
The concentration distribution of the various complex species in solution has been evaluated as a function of pH.
It has been found that in these dipeptides, [–C(O)O−, N−, NH2] coordinated complexes are dominant in the neutral pH range with a trigonal-bipyramidal structure.
The complex species formed are water soluble in the pH range 2.7–10.5.
In all of the studied systems, no polymeric species have been detected in the experimental pH range.
Beyond pH 8.0, significant amounts of hydroxo species, namely.
Me3Sn(OH) and Me2Sn(OH)2, are formed.
American Psychological Association (APA)
Nath, Mala& Sulaxna, & Song, Xueqing& Eng, George. 2012. New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions : Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium. ISRN Spectroscopy،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-478019
Modern Language Association (MLA)
Nath, Mala…[et al.]. New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions : Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium. ISRN Spectroscopy No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-478019
American Medical Association (AMA)
Nath, Mala& Sulaxna, & Song, Xueqing& Eng, George. New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions : Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium. ISRN Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-478019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478019