Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections
Joint Authors
Perumal Samy, Ramar
Manikandan, Jayapal
al-Qahtani, Mohammed
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Traditional medicine plays a vital role for primary health care in India, where it is widely practiced to treat various ailments.
Among those obtained from the healers, 78 medicinal plants were scientifically evaluated for antibacterial activity.
Methanol extract of plants (100 μg of residue) was tested against the multidrug resistant (MDR) Gram-negative and Gram-positive bacteria.
Forty-seven plants showed strong activity against Burkholderia pseudomallei (strain TES and KHW) and Staphylococcus aureus, of which Tragia involucrata L., Citrus acida Roxb.
Hook.f., and Aegle marmelos (L.) Correa ex Roxb.
showed powerful inhibition of bacteria.
Eighteen plants displayed only a moderate effect, while six plants failed to provide any evidence of inhibition against the tested bacteria.
Purified compounds showed higher antimicrobial activity than crude extracts.
The compounds showed less toxic effect to the human skin fibroblasts (HEPK) cells than their corresponding aromatic fractions.
Phytochemical screening indicates that the presence of various secondary metabolites may be responsible for this activity.
Most of the plant extracts contained high levels of phenolic or polyphenolic compounds and exhibited activity against MDR pathogens.
In conclusion, plants are promising agents that deserve further exploration.
Lead molecules available from such extracts may serve as potential antimicrobial agents for future drug development to combat diseases caused by the MDR bacterial strains as reported in this study.
American Psychological Association (APA)
Perumal Samy, Ramar& Manikandan, Jayapal& al-Qahtani, Mohammed. 2013. Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-478642
Modern Language Association (MLA)
Perumal Samy, Ramar…[et al.]. Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-478642
American Medical Association (AMA)
Perumal Samy, Ramar& Manikandan, Jayapal& al-Qahtani, Mohammed. Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-478642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478642