MRMPath and MRMutation, Facilitating Discovery of Mass Transitions for Proteotypic Peptides in Biological Pathways Using a Bioinformatics Approach
Joint Authors
Crasto, Chiquito
Narne, Chandrahas
Wilson, Landon
Kawai, Mikako
Barnes, Stephen
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Quantitative proteomics applications in mass spectrometry depend on the knowledge of the mass-to-charge ratio (m/z) values of proteotypic peptides for the proteins under study and their product ions.
MRMPath and MRMutation, web-based bioinformatics software that are platform independent, facilitate the recovery of this information by biologists.
MRMPath utilizes publicly available information related to biological pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database.
All the proteins involved in pathways of interest are recovered and processed in silico to extract information relevant to quantitative mass spectrometry analysis.
Peptides may also be subjected to automated BLAST analysis to determine whether they are proteotypic.
MRMutation catalogs and makes available, following processing, known (mutant) variants of proteins from the current UniProtKB database.
All these results, available via the web from well-maintained, public databases, are written to an Excel spreadsheet, which the user can download and save.
MRMPath and MRMutation can be freely accessed.
As a system that seeks to allow two or more resources to interoperate, MRMPath represents an advance in bioinformatics tool development.
As a practical matter, the MRMPath automated approach represents significant time savings to researchers.
American Psychological Association (APA)
Crasto, Chiquito& Narne, Chandrahas& Kawai, Mikako& Wilson, Landon& Barnes, Stephen. 2013. MRMPath and MRMutation, Facilitating Discovery of Mass Transitions for Proteotypic Peptides in Biological Pathways Using a Bioinformatics Approach. Advances in Bioinformatics،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478781
Modern Language Association (MLA)
Crasto, Chiquito…[et al.]. MRMPath and MRMutation, Facilitating Discovery of Mass Transitions for Proteotypic Peptides in Biological Pathways Using a Bioinformatics Approach. Advances in Bioinformatics No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-478781
American Medical Association (AMA)
Crasto, Chiquito& Narne, Chandrahas& Kawai, Mikako& Wilson, Landon& Barnes, Stephen. MRMPath and MRMutation, Facilitating Discovery of Mass Transitions for Proteotypic Peptides in Biological Pathways Using a Bioinformatics Approach. Advances in Bioinformatics. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478781