Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans
Joint Authors
Lee, Hojun
Veerabhadrappa, Praveen
Williamson, Sheara T.
Kashem, Mohammed A.
Kretzschmar, Jan
Crabbe, Deborah L.
Thakkar, Sunny R.
Grimm, Heather
Babbitt, Dianne M.
Brown, Michael D.
Diaz, Keith M.
Sturgeon, Kathleen M.
Feairheller, Deborah L.
Ling, Chenyi
Perkins, Amanda M.
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation.
The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and endothelial microparticle (EMP) CD62E+ and endothelial function assessed by flow-mediated dilation (FMD) in African Americans.
A secondary purpose was to evaluate whether changes in IL-10, IL-6, or CD62E+ EMPs predicted the change in FMD following the 6-month AEXT intervention.
A pre-post design was employed with baseline evaluation including office blood pressure, FMD, fasting blood sampling, and graded exercise testing.
Participants engaged in 6 months of AEXT.
Following the AEXT intervention, all baseline tests were repeated.
FMD significantly increased, CD62E+ EMPs and IL-6 significantly decreased, and IL-10 increased but not significantly following AEXT.
Changes in inflammatory biomarkers did not significantly predict the change in FMD.
The change in VO2 max significantly predicted the change in IL-10.
Based on these results, AEXT may be a viable, nonpharmacological method to improve inflammation status and endothelial function and thereby contribute to risk reduction for cardiovascular disease in African Americans.
American Psychological Association (APA)
Babbitt, Dianne M.& Diaz, Keith M.& Feairheller, Deborah L.& Sturgeon, Kathleen M.& Perkins, Amanda M.& Veerabhadrappa, Praveen…[et al.]. 2013. Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-479670
Modern Language Association (MLA)
Babbitt, Dianne M.…[et al.]. Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans. International Journal of Hypertension No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-479670
American Medical Association (AMA)
Babbitt, Dianne M.& Diaz, Keith M.& Feairheller, Deborah L.& Sturgeon, Kathleen M.& Perkins, Amanda M.& Veerabhadrappa, Praveen…[et al.]. Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-479670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479670