Varicose Veins : Role of Mechanotransduction of Venous Hypertension
Author
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Varicose veins affect approximately one-third of the adult population and result in significant psychological, physical, and financial burden.
Nevertheless, the molecular pathogenesis of varicose vein formation remains unidentified.
Venous hypertension exerted on veins of the lower extremity is considered the principal factor in varicose vein formation.
The role of mechanotransduction of the high venous pressure in the pathogenesis of varicose vein formation has not been adequately investigated despite a good progress in understanding the mechanomolecular mechanisms involved in transduction of high blood pressure in the arterial wall.
Understanding the nature of the mechanical forces, the mechanosensors and mechanotransducers in the vein wall, and the downstream signaling pathways will provide new molecular targets for the prevention and treatment of varicose veins.
This paper summarized the current understanding of mechano-molecular pathways involved in transduction of hemodynamic forces induced by blood pressure and tries to relate this information to setting of venous hypertension in varicose veins.
American Psychological Association (APA)
Atta, Hussein M.. 2012. Varicose Veins : Role of Mechanotransduction of Venous Hypertension. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-479725
Modern Language Association (MLA)
Atta, Hussein M.. Varicose Veins : Role of Mechanotransduction of Venous Hypertension. International Journal of Vascular Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-479725
American Medical Association (AMA)
Atta, Hussein M.. Varicose Veins : Role of Mechanotransduction of Venous Hypertension. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-479725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479725