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The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content
Joint Authors
Settaf, Abdellatif
Martineau, Louis C.
Haddad, Pierre S.
Madiraju, Padma
Vuong, Tri
Meddah, Bouchra
Benhaddou-Andaloussi, Ali
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The antidiabetic effect of N.
sativa seed ethanol extract (NSE) was assessed in Meriones shawi after development of diabetes.
Meriones shawi were divided randomly into four groups: normal control, diabetic control, diabetic treated with NSE (2 g eq plant/kg) or with metformin (300 mg/kg) positive control, both administered by daily intragastric gavage for 4 weeks.
Glycaemia and body weight were evaluated weekly.
At study's end, an Oral Glucose Tolerance Test (OGTT) was performed to estimate insulin sensitivity.
Upon sacrifice, plasma lipid profile, insulin, leptin, and adiponectin levels were assessed.
ACC phosphorylation and Glut4 protein content were determined in liver and skeletal muscle.
NSE animals showed a progressive normalization of glycaemia, albeit slower than that of metformin controls.
Moreover, NSE increased insulinemia and HDL-cholesterol, compared to diabetic controls.
Leptin and adiponectin were unchanged.
NSE treatment decreased OGTT and tended to decrease liver and muscle triglyceride content.
NSE stimulated muscle and liver ACC phosphorylation and increased muscle Glut4.
These results confirm NSE's previously reported hypoglycaemic and hypolipidemic activity.
More significantly, our data demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major component of the insulin-independent AMPK signaling pathway, and by enhancing muscle Glut4 expression.
American Psychological Association (APA)
Benhaddou-Andaloussi, Ali& Martineau, Louis C.& Vuong, Tri& Meddah, Bouchra& Madiraju, Padma& Settaf, Abdellatif…[et al.]. 2011. The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479730
Modern Language Association (MLA)
Benhaddou-Andaloussi, Ali…[et al.]. The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-479730
American Medical Association (AMA)
Benhaddou-Andaloussi, Ali& Martineau, Louis C.& Vuong, Tri& Meddah, Bouchra& Madiraju, Padma& Settaf, Abdellatif…[et al.]. The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479730