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Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine
Joint Authors
Yang, Hong-Ju
Wang, Lijun
Cheng, Qiang
Xu, Haiyun
Source
Schizophrenia Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Amphetamine (AMP) is an addictive CNS stimulant and has been commonly abused by adolescents and young adults, during which period brain white matter is still developing.
This study was to examine the effect of a nonneurotoxic AMP on the white matter of juvenile mice.
d-AMP (1.0 mg/kg) was given to young male C57BL/6 mice once a day for 21 days.
The spatial working memory and locomotion of mice were measured at the end.
Then, mice were sacrificed and their brains were processed for morphological analyses to examine the white matter structure and for Western blot analysis to measure three main proteins expressed in mature oligodendrocytes.
AMP-treated mice displayed higher locomotion and spatial working memory impairment and showed lower levels of Nogo-A and GST-pi proteins in frontal cortex and lower MBP protein in the frontal cortex and hippocampus.
They also had fewer mature oligodendrocytes and weak MBP immunofluorescent staining in the same two brain regions.
But the striatum was spared.
These results suggest that the late-developing white matter is vulnerable to AMP treatment which is able to increase striatal and cortical dopamine.
Both the compromised white matter and increased dopamine may contribute to the observed behavioral changes in AMP-treated mice.
American Psychological Association (APA)
Yang, Hong-Ju& Wang, Lijun& Cheng, Qiang& Xu, Haiyun. 2011. Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine. Schizophrenia Research and Treatment،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480143
Modern Language Association (MLA)
Yang, Hong-Ju…[et al.]. Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine. Schizophrenia Research and Treatment No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-480143
American Medical Association (AMA)
Yang, Hong-Ju& Wang, Lijun& Cheng, Qiang& Xu, Haiyun. Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine. Schizophrenia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480143