Florbetaben PET in the Early Diagnosis of Alzheimer's Disease : A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps
Joint Authors
Blankenburg, Michael
Lanes, Stephan
Getsios, Denis
Altincatal, Arman
Lawler, Elizabeth V.
Cho, Kelly
Guo, Shien
Hernandez, Luis
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The growing understanding of the use of biomarkers in Alzheimer's disease (AD) may enable physicians to make more accurate and timely diagnoses.
Florbetaben, a beta-amyloid tracer used with positron emission tomography (PET), is one of these diagnostic biomarkers.
This analysis was undertaken to explore the potential value of florbetaben PET in the diagnosis of AD among patients with suspected dementia and to identify key data that are needed to further substantiate its value.
A discrete event simulation was developed to conduct exploratory analyses from both US payer and societal perspectives.
The model simulates the lifetime course of disease progression for individuals, evaluating the impact of their patient management from initial diagnostic work-up to final diagnosis.
Model inputs were obtained from specific analyses of a large longitudinal dataset from the New England Veterans Healthcare System and supplemented with data from public data sources and assumptions.
The analyses indicate that florbetaben PET has the potential to improve patient outcomes and reduce costs under certain scenarios.
Key data on the use of florbetaben PET, such as its influence on time to confirmation of final diagnosis, treatment uptake, and treatment persistency, are unavailable and would be required to confirm its value.
American Psychological Association (APA)
Guo, Shien& Getsios, Denis& Hernandez, Luis& Cho, Kelly& Lawler, Elizabeth V.& Altincatal, Arman…[et al.]. 2012. Florbetaben PET in the Early Diagnosis of Alzheimer's Disease : A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-480524
Modern Language Association (MLA)
Guo, Shien…[et al.]. Florbetaben PET in the Early Diagnosis of Alzheimer's Disease : A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-480524
American Medical Association (AMA)
Guo, Shien& Getsios, Denis& Hernandez, Luis& Cho, Kelly& Lawler, Elizabeth V.& Altincatal, Arman…[et al.]. Florbetaben PET in the Early Diagnosis of Alzheimer's Disease : A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-480524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480524