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Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug
Joint Authors
Ghosh, Suparna
Bhattacharya, Mamta
Malik, Suman
Singh, Archana
Jain, Bharti
Source
International Journal of Inorganic Chemistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from xipamide, a diuretic drug.
The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio.
Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized.
The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis.
The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L].
All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements.
Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms.
Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex.
The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus.
The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.
American Psychological Association (APA)
Malik, Suman& Ghosh, Suparna& Jain, Bharti& Singh, Archana& Bhattacharya, Mamta. 2013. Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug. International Journal of Inorganic Chemistry،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480712
Modern Language Association (MLA)
Malik, Suman…[et al.]. Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug. International Journal of Inorganic Chemistry No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-480712
American Medical Association (AMA)
Malik, Suman& Ghosh, Suparna& Jain, Bharti& Singh, Archana& Bhattacharya, Mamta. Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug. International Journal of Inorganic Chemistry. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480712