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Innervation of a Prefabricated Flap : A New Experimental Model
Joint Authors
Cuccia, Giuseppe
Romeo, Marco
Geuna, Stefano
Hontanilla, Bernardo
Raimondo, Stefania
Qiu, Shan Shan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Flap innervation by neoaxonogenesis is a promising field of investigation.
The authors evaluated the possibility of innervating an acellular collagen scaffold as component of a potential prefabricated flap.
Materials and Methods.
Collagen matrix sheets were implanted around the femoral bundle of a murine model to produce two flaps on proximal and distal nerve stumps based on a flow-through model.
After thirty days, nerve regeneration and integration into the collagen matrix were evaluated.
The specimens were microscopically analyzed to study Schwann cell colonization and axonal integration with the matrix.
Axonal count and density were assessed and statistically evaluated.
Results.
Qualitative structural and ultrastructural evaluation indicated integration, with axonal fibers merged within the collagen matrix, along with a newly formed vascular network on the proximal flap.
Wallerian degeneration occurred inside the distal chamber.
Axonal count and density did not show statistically significant differences between the nerve inside the proximal flap and the control side.
Conclusions.
Innervation of an acellular matrix can be obtained by direct nerve stump implantation.
The flow-through system was relatively easy to build and reliable to provide adequate blood supply.
The collagen scaffold may be a promising support or further studies of preinnervated microsurgical flaps.
American Psychological Association (APA)
Romeo, Marco& Cuccia, Giuseppe& Qiu, Shan Shan& Raimondo, Stefania& Geuna, Stefano& Hontanilla, Bernardo. 2014. Innervation of a Prefabricated Flap : A New Experimental Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-480714
Modern Language Association (MLA)
Romeo, Marco…[et al.]. Innervation of a Prefabricated Flap : A New Experimental Model. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-480714
American Medical Association (AMA)
Romeo, Marco& Cuccia, Giuseppe& Qiu, Shan Shan& Raimondo, Stefania& Geuna, Stefano& Hontanilla, Bernardo. Innervation of a Prefabricated Flap : A New Experimental Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-480714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480714