Investigational Paradigms in Downscoring and Upscoring DCIS : Surgical Management Review
Joint Authors
Orsaria, Paolo
Buonomo, Oreste Claudio
Venditti, D.
Petrella, Giuseppe
Granai, Alessandra Vittoria
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Counseling patients with DCIS in a rational manner can be extremely difficult when the range of treatment criteria results in diverse and confusing clinical recommendations.
Surgeons need tools that quantify measurable prognostic factors to be used in conjunction with clinical experience for the complex decision-making process.
Combination of statistically significant tumor recurrence predictors and lesion parameters obtained after initial excision suggests that patients with DCIS can be stratified into specific subsets allowing a scientifically based discussion.
The goal is to choose the treatment regimen that will significantly benefit each patient group without subjecting the patients to unnecessary risks.
Exploring the effectiveness of complete excision may offer a starting place in a new way of reasoning and conceiving surgical modalities in terms of “downscoring” or “upscoring” patient risk, perhaps changing clinical approach.
Reexcison may lower the specific subsets' score and improve local recurrence-free survival also by revealing a larger tumor size, a higher nuclear grade, or an involved margin and so suggesting the best management.
It seems, that the key could be identifying significant relapse predictive factors, according to validated risk investigation models, whose value is modifiable by the surgical approach which avails of different diagnostic and therapeutic potentials to be optimal.
Certainly DCIS clinical question cannot have a single curative mode due to heterogeneity of pathological lesions and histologic classification.
American Psychological Association (APA)
Orsaria, Paolo& Granai, Alessandra Vittoria& Venditti, D.& Petrella, Giuseppe& Buonomo, Oreste Claudio. 2012. Investigational Paradigms in Downscoring and Upscoring DCIS : Surgical Management Review. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480775
Modern Language Association (MLA)
Orsaria, Paolo…[et al.]. Investigational Paradigms in Downscoring and Upscoring DCIS : Surgical Management Review. International Journal of Surgical Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-480775
American Medical Association (AMA)
Orsaria, Paolo& Granai, Alessandra Vittoria& Venditti, D.& Petrella, Giuseppe& Buonomo, Oreste Claudio. Investigational Paradigms in Downscoring and Upscoring DCIS : Surgical Management Review. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480775