Neurodegenerative Diseases : Multifactorial Conformational Diseases and Their Therapeutic Interventions
Joint Authors
Haque, Ejazul
Sheikh, Saba
Mir, Snober S.
Safia,
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neurodegenerative diseases are multifactorial debilitating disorders of the nervous system that affect approximately 30 millionindividuals worldwide.
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis diseases are the consequence of misfolding and dysfunctional trafficking of proteins.
Beside that, mitochondrial dysfunction, oxidative stress, and/or environmental factors strongly associated with age have also been implicated in causing neurodegeneration.
After years of intensive research, considerable evidence has accumulated that demonstrates an important role of these factors in the etiology of common neurodegenerative diseases.
Despite the extensive efforts that have attempted to define the molecular mechanisms underlying neurodegeneration, many aspects of these pathologies remain elusive.
However, in order to explore the therapeutic interventions directed towards treatment of neurodegenerative diseases, neuroscientists are now fully exploiting the data obtained from studies of these basic mechanisms that have gone awry.
The novelty of these mechanisms represents a challenge to the identification of viable drug targets and biomarkers for early diagnosis of the diseases.
In this paper, we are reviewing various aspects associated with the disease and the recent trends that may have an application for the treatment of the neurodegenerative disorders.
American Psychological Association (APA)
Sheikh, Saba& Safia, & Haque, Ejazul& Mir, Snober S.. 2012. Neurodegenerative Diseases : Multifactorial Conformational Diseases and Their Therapeutic Interventions. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481057
Modern Language Association (MLA)
Sheikh, Saba…[et al.]. Neurodegenerative Diseases : Multifactorial Conformational Diseases and Their Therapeutic Interventions. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-481057
American Medical Association (AMA)
Sheikh, Saba& Safia, & Haque, Ejazul& Mir, Snober S.. Neurodegenerative Diseases : Multifactorial Conformational Diseases and Their Therapeutic Interventions. Journal of Neurodegenerative Diseases. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481057