Early Onset Multiple Sclerosis Has Worse Prognosis Than Adult Onset Multiple Sclerosis Based on Cognition and Magnetic Resonance Imaging

Joint Authors

Özakbaş, Serkan
Kaya, Derya
Idiman, Egemen

Source

Autoimmune Diseases

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-11-07

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases

Abstract EN

Objectives.

In the present study, we aimed to compare the childhood and adult onset multiple sclerosis patients prospectively in their adulthood on the basis of clinical and magnetic resonance imaging (MRI) findings and cognitive impairment, which have not been performed before.

Patients and Methods.

Forty-six patients in whom the disease onset occurred before 16 years of age were included in the present study.

Study subjects were compared with 64 randomly included adult onset patients.

Results.

Mean disease duration, clinical course, and female to male ratio did not differ in the groups.

Cerebellar/brainstem and spinal involvement at onset were significantly higher in EOMS than in AOMS.

Difference in MSFC between baseline and at the end of the 5th year was significantly worse in EOMS population (P=0.02).

The most significant difference was found in Paced Auditory Serial Addition Test (PASAT) (P=0.008).

Differences between baseline and at the end of the 5th year on the basis of T1 hypointense lesions were significantly higher in early onset MS than in adult onset MS patients (P=0.02).

Conclusions.

Early onset MS seems to have worse prognosis than that of adult onset MS on the basis of clinical manifestation, cognitive impairment, and MRI parameters.

American Psychological Association (APA)

Özakbaş, Serkan& Kaya, Derya& Idiman, Egemen. 2012. Early Onset Multiple Sclerosis Has Worse Prognosis Than Adult Onset Multiple Sclerosis Based on Cognition and Magnetic Resonance Imaging. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481094

Modern Language Association (MLA)

Özakbaş, Serkan…[et al.]. Early Onset Multiple Sclerosis Has Worse Prognosis Than Adult Onset Multiple Sclerosis Based on Cognition and Magnetic Resonance Imaging. Autoimmune Diseases No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-481094

American Medical Association (AMA)

Özakbaş, Serkan& Kaya, Derya& Idiman, Egemen. Early Onset Multiple Sclerosis Has Worse Prognosis Than Adult Onset Multiple Sclerosis Based on Cognition and Magnetic Resonance Imaging. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481094

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-481094