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Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases : A Single Institution Experience
Joint Authors
Gamblin, T. Clark
Joyce, Judith
Nastasi, Bryon E.
Zajko, Albert
Amesur, Nikhil
Nace, Gary W.
Sheetz, Michael
Steel, Jennifer L.
Source
International Journal of Surgical Oncology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
We sought to evaluate our experience using yttrium-90 (90Y) resin microsphere hepatic radioembolization as salvage therapy for liver-dominant metastatic colorectal cancer (mCRC).
Methods.
A retrospective review of consecutive patients with unresectable mCRC who were treated with 90Y after failing first and second line systemic chemotherapy.
Demographics, treatment dose, biochemical and radiographic response, toxicities, and survival were examined.
Results.
Fifty-one patients underwent 90Y treatments of which 69% were male.
All patients had previously undergone extensive chemotherapy, 31% had undergone previous liver-directed therapy and 24% had a prior liver resection.
Using RECIST criteria, either stable disease or a partial response was seen in 77% of patients.
Overall median survival from the time of first 90Y treatment was 10.2 months (95% CI = 7.5–13.0).
The absence of extrahepatic disease at the time of treatment with 90Y was associated with an improved survival, median survival of 17.0 months (95% CI = 6.4–27.6), compared to those with extrahepatic disease at the time of treatment with 90Y, 6.7 months (95% CI = 2.7–10.6 Conclusion: 90Y therapy is a safe locoregional therapy that provides an important therapeutic option to patients who have failed first and second line chemotherapy and have adequate liver function and performance status.
American Psychological Association (APA)
Nace, Gary W.& Steel, Jennifer L.& Amesur, Nikhil& Zajko, Albert& Nastasi, Bryon E.& Joyce, Judith…[et al.]. 2011. Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases : A Single Institution Experience. International Journal of Surgical Oncology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481640
Modern Language Association (MLA)
Nace, Gary W.…[et al.]. Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases : A Single Institution Experience. International Journal of Surgical Oncology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-481640
American Medical Association (AMA)
Nace, Gary W.& Steel, Jennifer L.& Amesur, Nikhil& Zajko, Albert& Nastasi, Bryon E.& Joyce, Judith…[et al.]. Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases : A Single Institution Experience. International Journal of Surgical Oncology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481640