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Twenty Years of Experience with the Preoperative Diagnosis of Medullary Cancer in a Moderately Iodine-Deficient Region
Joint Authors
Lukacs Toth, Gyula
Nagy, Dezso
Gal, Istvan
Solymosi, Tamas
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
There is a current debate in the medical literature about plasma calcitonin screening in patients with nodular goiter (NG).
We decided on analyzing our 20-year experience with patients in an iodine-deficient region (ID).
Patients and Methods.
22,857 consecutive patients with NG underwent ultrasonography and aspiration cytology (FNAC).
If FNAC raised suspicion of medullary cancer (MTC), the serum calcitonin was measured.
Results.
4,601 patients underwent surgery; there were 23 patients among them who had MTC (0.1% prevalence).
Significantly more MTC cases were diagnosed cytologically in the second decade than in the first: 11/12 and 6/11, respectively.
The frozen section was of help in 2 cases out of 3.
Two patients suffered from a 3-year delay in proper therapy, and reoperation was necessary in 1 case.
FNAC raised the suspicion of MTC in 20 cases that were later histologically verified and did not present MTC.
The diagnostic accuracy of FNAC in diagnosing MTC was 99.2%.
Two false-positive serum calcitonin tests (one of them in a hemodialyzed patient) and one false-negative serum calcitonin test occurred in 40 cases.
Conclusion.
Regarding the low prevalence of MTC in ID regions, calcitonin screening of all NG patients does not only appear superfluously but may have more disadvantages than advantages.
American Psychological Association (APA)
Solymosi, Tamas& Lukacs Toth, Gyula& Nagy, Dezso& Gal, Istvan. 2013. Twenty Years of Experience with the Preoperative Diagnosis of Medullary Cancer in a Moderately Iodine-Deficient Region. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-481684
Modern Language Association (MLA)
Solymosi, Tamas…[et al.]. Twenty Years of Experience with the Preoperative Diagnosis of Medullary Cancer in a Moderately Iodine-Deficient Region. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-481684
American Medical Association (AMA)
Solymosi, Tamas& Lukacs Toth, Gyula& Nagy, Dezso& Gal, Istvan. Twenty Years of Experience with the Preoperative Diagnosis of Medullary Cancer in a Moderately Iodine-Deficient Region. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-481684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481684