Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol Challenges
Joint Authors
Rhoads, Dennis E.
Contreras, Cherly
Fathalla, Salma
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Catalase (EC 1.11.1.6) oxidizes ethanol to acetaldehyde within the brain and variations in catalase activity may underlie some consequences of ethanol consumption.
The goals of this study were to measure catalase activity in subcellular fractions from rat brain and to compare the levels of this enzyme in several important settings.
In the first series of studies, levels of catalase were compared between juvenile and adult rats and between the Long-Evans (LE) and Sprague-Dawley (SD) strains.
Levels of catalase appear to have achieved the adult level by the preadolescent period defined by postnatal age (P, days) P25–P28, and there were no differences between strains at the developmental stages tested.
Thus, variation in catalase activity is unlikely to be responsible for differences in how adolescent and adult rats respond to ethanol.
In the second series of studies, periadolescent and adult rats were administered ethanol chronically through an ethanol-containing liquid diet.
Diet consumption and blood ethanol concentrations were significantly higher for periadolescent rats.
Catalase activities remained unchanged following ethanol consumption, with no significant differences within or between strains.
Thus, the brain showed no apparent adaptive changes in levels of catalase, even when faced with the high levels of ethanol consumption characteristic of periadolescent rats.
American Psychological Association (APA)
Rhoads, Dennis E.& Contreras, Cherly& Fathalla, Salma. 2012. Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol Challenges. Enzyme Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-481822
Modern Language Association (MLA)
Rhoads, Dennis E.…[et al.]. Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol Challenges. Enzyme Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-481822
American Medical Association (AMA)
Rhoads, Dennis E.& Contreras, Cherly& Fathalla, Salma. Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol Challenges. Enzyme Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-481822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481822