The Effect of Beta-Aminopropionitrile and Prednisolone on the Prevention of Fibrosis in Alkali Esophageal Burns : An Experimental Study
Joint Authors
Eser, Mediha
Yanar, Hakan Teoman
Gulcin, Hepgul E.
Agcaoglu, Orhan
Dogan, Halil
Ayvaci, Baris Murat
Celikmen, Ferudun
Aciksari, Kurtulus
Gunay, Kayihan
Topacoglu, Hakan
Yanar, Fatih
Ertekin, Cemalettin
Tanriverdi, Gamze
Ozucelik, Dogac Niyazi
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of this study was to investigate the efficacy of beta-aminopropionitrile (BAPN) and prednisolone on the prevention of esophageal damage and stricture formation after caustic esophageal burn.
Method.
Twenty-eight rats were divided into four equal groups.
In groups 1, 2, and 3, caustic esophageal burns were generated by applying NaOH to the 1.5 cm segment of the abdominal esophagus.
Group 4 was for the sham.
Normal saline to group 1, BAPN to group 2, and prednisolone to group 3 were administered intraperitoneally as a single daily dose.
Results.
Treatment with BAPN decreased the stenosis index (SI) and histopathologic damage score (HDS) seen in caustic esophageal burn rats.
The SI in group 4 was significantly lower compared with groups 1, 2, and 3.
Group 2 had the minimum SI value in corrosive burn groups.
The differences related to SI between groups 1, 2, and 3 were not statistically significant.
The HDS was significantly lower in group 4 compared with groups 1, 2, and 3.
The HDS in group 2 was significantly lower compared with groups 1 and 3.
Conclusion.
This study demonstrated that BAPN was able to decrease the development of stenosis and tissue damage better than prednisolone.
American Psychological Association (APA)
Aciksari, Kurtulus& Yanar, Hakan Teoman& Gulcin, Hepgul E.& Ozucelik, Dogac Niyazi& Yanar, Fatih& Agcaoglu, Orhan…[et al.]. 2013. The Effect of Beta-Aminopropionitrile and Prednisolone on the Prevention of Fibrosis in Alkali Esophageal Burns : An Experimental Study. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-481943
Modern Language Association (MLA)
Aciksari, Kurtulus…[et al.]. The Effect of Beta-Aminopropionitrile and Prednisolone on the Prevention of Fibrosis in Alkali Esophageal Burns : An Experimental Study. Gastroenterology Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-481943
American Medical Association (AMA)
Aciksari, Kurtulus& Yanar, Hakan Teoman& Gulcin, Hepgul E.& Ozucelik, Dogac Niyazi& Yanar, Fatih& Agcaoglu, Orhan…[et al.]. The Effect of Beta-Aminopropionitrile and Prednisolone on the Prevention of Fibrosis in Alkali Esophageal Burns : An Experimental Study. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-481943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481943