Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma
Joint Authors
Yang, Wentao
Huang, Xiaowei
Shi, Daren
Ren, Yulan
Lu, Yongming
Wang, Huaying
Zhou, Xiaoyan
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To analyze clinico-pathological features of Chinese patients with UPSC, and investigate roles of Her-2/neu protein expression and gene amplification in UPSC prognosis.
Methods.
Thirty-six patients with UPSC treated in Cancer Hospital of Fudan University from 1996 to 2006 were analysed retrospectively.
Chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) were performed to evaluate Her-2/neu gene amplification and protein expression respectively.
Results.
The median age was 63 years, and 61% (22/36) were late stages (stage III/IV).
The 1-year, 3-year, and 5-year overall survival (OS) was 73.1%, 51.9% and 43.9%, respectively.
Advanced stages (P=.0006) and deep myometrial invasion (P=.0138) were significantly associtated with a shorter OS.
In 36 cases, 27.8% (10/36) showed 2+ staining and 8.3% (3/36) showed 3+ by IHC.
Amplification of the Her-2/neu gene was observed in 11.1% (4/36) cases.
The 5-year overall survival rate in Her-2/neu IHC 2+∼3+ and 0∼1+ cases was 12.9% and 68.6% respectively.
Her-2/neu protein expression 2+∼3+ was significantly associated with advanced surgical stage and worse overall survival (P=.03 and P=.0023, resp.).
Conclusion.
Chinese patients with UPSC showed characteristics of deep myometrial invasion, advanced stages and poor overall survival.
Her-2/neu protein overexpression is associated with advanced stage and poor survival outcome.
American Psychological Association (APA)
Ren, Yulan& Wang, Huaying& Zhou, Xiaoyan& Yang, Wentao& Huang, Xiaowei& Lu, Yongming…[et al.]. 2010. Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482028
Modern Language Association (MLA)
Ren, Yulan…[et al.]. Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-482028
American Medical Association (AMA)
Ren, Yulan& Wang, Huaying& Zhou, Xiaoyan& Yang, Wentao& Huang, Xiaowei& Lu, Yongming…[et al.]. Clinicopathological Characteristics and Her-2neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma. ISRN Obstetrics and Gynecology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482028