Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders
Joint Authors
Crook, Tina A.
Melnyk, Stepan
Starrett, William
Pauly, Margaret
Pavliv, Oleksandra
James, S. Jill
Hamlin, Joanna C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Abnormalities in folate-dependent one-carbon metabolism have been reported in many children with autism.
Because inadequate choline and betaine can negatively affect folate metabolism and in turn downstream methylation and antioxidant capacity, we sought to determine whether dietary intake of choline and betaine in children with autism was adequate to meet nutritional needs based on national recommendations.
Three-day food records were analyzed for 288 children with autism (ASDs) who participated in the national Autism Intervention Research Network for Physical Health (AIR-P) Study on Diet and Nutrition in children with autism.
Plasma concentrations of choline and betaine were measured in a subgroup of 35 children with ASDs and 32 age-matched control children.
The results indicated that 60–93% of children with ASDs were consuming less than the recommended Adequate Intake (AI) for choline.
Strong positive correlations were found between dietary intake and plasma concentrations of choline and betaine in autistic children as well as lower plasma concentrations compared to the control group.
We conclude that choline and betaine intake is inadequate in a significant subgroup of children with ASDs and is reflected in lower plasma levels.
Inadequate intake of choline and betaine may contribute to the metabolic abnormalities observed in many children with autism and warrants attention in nutritional counseling.
American Psychological Association (APA)
Hamlin, Joanna C.& Pauly, Margaret& Melnyk, Stepan& Pavliv, Oleksandra& Starrett, William& Crook, Tina A.…[et al.]. 2013. Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders. Autism Research and Treatment،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482224
Modern Language Association (MLA)
Hamlin, Joanna C.…[et al.]. Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders. Autism Research and Treatment No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-482224
American Medical Association (AMA)
Hamlin, Joanna C.& Pauly, Margaret& Melnyk, Stepan& Pavliv, Oleksandra& Starrett, William& Crook, Tina A.…[et al.]. Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders. Autism Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482224