Continuous Spikes and Waves during Sleep : Electroclinical Presentation and Suggestions for Management
Joint Authors
Peters, Jurriaan M.
Harini, Chellamani
Sánchez Fernández, Iván
Loddenkemper, Tobias
Chapman, Kevin E.
Rotenberg, Alexander
Source
Epilepsy Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Continuous spikes and waves during sleep (CSWS) is an epileptic encephalopathy characterized in most patients by (1) difficult to control seizures, (2) interictal epileptiform activity that becomes prominent during sleep leading to an electroencephalogram (EEG) pattern of electrical status epilepticus in sleep (ESES), and (3) neurocognitive regression.
In this paper, we will summarize current epidemiological, clinical, and EEG knowledge on CSWS and will provide suggestions for treatment.
CSWS typically presents with seizures around 2–4 years of age.
Neurocognitive regression occurs around 5-6 years of age, and it is accompanied by subacute worsening of EEG abnormalities and seizures.
At approximately 6–9 years of age, there is a gradual resolution of seizures and EEG abnormalities, but the neurocognitive deficits persist in most patients.
The cause of CSWS is unknown, but early developmental lesions play a major role in approximately half of the patients, and genetic associations have recently been described.
High-dose benzodiazepines and corticosteroids have been successfully used to treat clinical and electroencephalographic features.
Corticosteroids are often reserved for refractory disease because of adverse events.
Valproate, ethosuximide, levetiracetam, sulthiame, and lamotrigine have been also used with some success.
Epilepsy surgery may be considered in a few selected patients.
American Psychological Association (APA)
Sánchez Fernández, Iván& Chapman, Kevin E.& Peters, Jurriaan M.& Harini, Chellamani& Rotenberg, Alexander& Loddenkemper, Tobias. 2013. Continuous Spikes and Waves during Sleep : Electroclinical Presentation and Suggestions for Management. Epilepsy Research and Treatment،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-482686
Modern Language Association (MLA)
Sánchez Fernández, Iván…[et al.]. Continuous Spikes and Waves during Sleep : Electroclinical Presentation and Suggestions for Management. Epilepsy Research and Treatment No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-482686
American Medical Association (AMA)
Sánchez Fernández, Iván& Chapman, Kevin E.& Peters, Jurriaan M.& Harini, Chellamani& Rotenberg, Alexander& Loddenkemper, Tobias. Continuous Spikes and Waves during Sleep : Electroclinical Presentation and Suggestions for Management. Epilepsy Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-482686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482686