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Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women : The Women's Health and Aging Study I
Joint Authors
Varadhan, Ravi
Fried, Linda P.
Sun, Kai
Semba, Richard D.
Schaumberg, Debra A.
Ferrucci, Luigi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia.
Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) over 30 months of followup in 394 moderately to severely disabled women, ≥65 years, living in the community in Baltimore, Maryland (the Women’s Health and Aging Study I).
During followup, 154 (26.4%) women developed severe walking disability, and 23 women died.
Women in the highest quartile of serum CML had increased risk of developing of severe walking disability in a multivariate Cox proportional hazards model, adjusting for age and other potential confounders.
Women with elevated serum CML are at an increased risk of developing severe walking disability.
AGEs are a potentially modifiable risk factor.
Further work is needed to establish a causal relationship between AGEs and walking disability.
American Psychological Association (APA)
Sun, Kai& Semba, Richard D.& Fried, Linda P.& Schaumberg, Debra A.& Ferrucci, Luigi& Varadhan, Ravi. 2012. Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women : The Women's Health and Aging Study I. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-482938
Modern Language Association (MLA)
Sun, Kai…[et al.]. Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women : The Women's Health and Aging Study I. Journal of Aging Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-482938
American Medical Association (AMA)
Sun, Kai& Semba, Richard D.& Fried, Linda P.& Schaumberg, Debra A.& Ferrucci, Luigi& Varadhan, Ravi. Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women : The Women's Health and Aging Study I. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-482938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482938