In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP
Joint Authors
Droog, Wouter
Batstra, Manou
Meynaar, Iwan A.
Vreede, Rolf
Herbrink, Paul
Source
Critical Care Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We studied the usefulness of serum procalcitonin (PCT), interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP) levels and C-reactive protein (CRP) levels, in differentiating between systemic inflammatory response syndrome (SIRS) and sepsis in critically ill patients.
Methods.
In this single centre prospective observational study we included all consecutive patients admitted with SIRS or sepsis to the ICU.
Blood samples for measuring CRP, PCT, IL-6 and LBP were taken every day until ICU discharge.
Results.
A total of 76 patients were included, 32 with sepsis and 44 with SIRS.
Patients with sepsis were sicker on admission and had a higher mortality.
CRP, PCT, IL-6 and LBP levels were significantly higher in patients with sepsis as compared to SIRS.
With PCT levels in the first 24 hours after ICU admission <2 ng/mL, ssepsis was virtually excluded (negative predictive value 97%).
With PCT >10 ng/mL, sepsis with bacterial infection was very likely (positive predictive value 88%).
PCT was best at discriminating between SIRS and sepsis with the highest area under the ROC curve (0.95, 95% CI 0.90–0.99).
Discussion.
This study showed that PCT is more useful than LBP, CRP and IL-6 in differentiating sepsis from SIRS.
American Psychological Association (APA)
Meynaar, Iwan A.& Droog, Wouter& Batstra, Manou& Vreede, Rolf& Herbrink, Paul. 2011. In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP. Critical Care Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-483640
Modern Language Association (MLA)
Meynaar, Iwan A.…[et al.]. In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP. Critical Care Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-483640
American Medical Association (AMA)
Meynaar, Iwan A.& Droog, Wouter& Batstra, Manou& Vreede, Rolf& Herbrink, Paul. In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP. Critical Care Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-483640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483640