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Cost-Effectiveness of Antiretroviral Therapy for Multidrug-Resistant HIV : Past, Present, and Future
Joint Authors
Harris, Marianne
Cohen, Calvin
Nosyk, Bohdan
Montaner, Julio S. G.
Harrigan, Richard
Lima, Viviane Dias
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the early years of the highly active antiretroviral therapy (HAART) era, HIV with resistance to two or more agents in different antiretroviral classes posed a significant clinical challenge.
Multidrug-resistant (MDR) HIV was an important cause of treatment failure, morbidity, and mortality.
Treatment options at the time were limited; multiple drug regimens with or without enfuvirtide were used with some success but proved to be difficult to sustain for reasons of tolerability, toxicity, and cost.
Starting in 2006, data began to emerge supporting the use of new drugs from the original antiretroviral classes (tipranavir, darunavir, and etravirine) and drugs from new classes (raltegravir and maraviroc) for the treatment of MDR HIV.
Their availability has enabled patients with MDR HIV to achieve full and durable viral suppression with more compact and cost-effective regimens including at least two and often three fully active agents.
The emergence of drug-resistant HIV is expected to continue to become less frequent in the future, driven by improvements in the convenience, tolerability, efficacy, and durability of first-line HAART regimens.
To continue this trend, the optimal rollout of HAART in both rich and resource-limited settings will require careful planning and strategic use of antiretroviral drugs and monitoring technologies.
American Psychological Association (APA)
Harris, Marianne& Nosyk, Bohdan& Harrigan, Richard& Lima, Viviane Dias& Cohen, Calvin& Montaner, Julio S. G.. 2012. Cost-Effectiveness of Antiretroviral Therapy for Multidrug-Resistant HIV : Past, Present, and Future. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483737
Modern Language Association (MLA)
Harris, Marianne…[et al.]. Cost-Effectiveness of Antiretroviral Therapy for Multidrug-Resistant HIV : Past, Present, and Future. AIDS Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-483737
American Medical Association (AMA)
Harris, Marianne& Nosyk, Bohdan& Harrigan, Richard& Lima, Viviane Dias& Cohen, Calvin& Montaner, Julio S. G.. Cost-Effectiveness of Antiretroviral Therapy for Multidrug-Resistant HIV : Past, Present, and Future. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483737