High-Grade Prostate Cancer : Favorable Results in the Modern Era Regardless of Initial Treatment
Joint Authors
Basler, Joseph W.
Swanson, Gregory P.
Ramahi, Emma H.
Jackson, Matthew W.
Du, Fei
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
We performed a retrospective study to determine the outcome of a modern cohort of patients with high-grade (Gleason score ≥ 8) prostate cancer treated with radical prostatectomy, radiation therapy, or hormone therapy.
Methods.
We identified 404 patients in the South Texas Veteran’s Healthcare System Tumor Registry diagnosed with high grade prostate cancer between 1998 and 2008.
Mean follow-up was 4.62 ± 2.61 years.
End points were biochemical failure-free survival, overall survival, metastasis-free survival, and cancer-specific survival.
Results.
5-year overall survival for patients undergoing radical prostatectomy, radiation therapy, and hormone therapy was 88.9%, 76.3%, and 58.9%, respectively.
5-year metastasis-free survival for patients undergoing radical prostatectomy, radiation therapy, and hormone therapy was 96.8%, 96.6%, and 88.4%, respectively, and 5-year cancer-specific survival was 97.2%, 100%, and 89.9%, respectively.
Patients with a Gleason score of 10 and pretreatment prostate-specific antigen > 20 ng/mL had decreased 5-year biochemical failure-free and cancer-specific survival.
Patients with a pretreatment prostate-specific antigen > 20 ng/mL had decreased 5-year overall survival.
Discussion.
Even for patients with high-grade disease, the outcome is not as dire in the modern era regardless of primary treatment modality chosen.
While there is room for improvement, we should not have a nihilistic impression of how these patients will respond to treatment.
American Psychological Association (APA)
Ramahi, Emma H.& Swanson, Gregory P.& Jackson, Matthew W.& Du, Fei& Basler, Joseph W.. 2012. High-Grade Prostate Cancer : Favorable Results in the Modern Era Regardless of Initial Treatment. ISRN Oncology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-483765
Modern Language Association (MLA)
Ramahi, Emma H.…[et al.]. High-Grade Prostate Cancer : Favorable Results in the Modern Era Regardless of Initial Treatment. ISRN Oncology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-483765
American Medical Association (AMA)
Ramahi, Emma H.& Swanson, Gregory P.& Jackson, Matthew W.& Du, Fei& Basler, Joseph W.. High-Grade Prostate Cancer : Favorable Results in the Modern Era Regardless of Initial Treatment. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-483765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483765