Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae)
Joint Authors
Biabiany, Murielle
Mahieux, Séverine
Sahpaz, Sevser
Roumy, Vincent
Standaert-Vitse, Annie
Rivière, Céline
Neut, Christel
Hennebelle, Thierry
Abedini, Amin
Bailleul, François
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Primary biological examination of four extracts of the leaves and stems of Hyptis atrorubens Poit.
(Lamiaceae), a plant species used as an antimicrobial agent in Guadeloupe, allowed us to select the hydromethanolic extract of the stems for further studies.
It was tested against 46 microorganisms in vitro.
It was active against 29 microorganisms.
The best antibacterial activity was found against bacteria, mostly Gram-positive ones.
Bioautography enabled the isolation and identification of four antibacterial compounds from this plant: rosmarinic acid, methyl rosmarinate, isoquercetin, and hyperoside.
The MIC and MBC values of these compounds and their combinations were determined against eight pathogenic bacteria.
The best inhibitory and bactericidal activity was found for methyl rosmarinate (0.3 mg/mL).
Nevertheless, the bactericidal power of rosmarinic acid was much faster in the time kill study.
Synergistic effects were found when combining the active compounds.
Finally, the inhibitory effects of the compounds were evaluated on the bacterial growth phases at two different temperatures.
Our study demonstrated for the first time antimicrobial activity of Hyptis atrorubens with identification of the active compounds.
It supports its traditional use in French West Indies.
Although its active compounds need to be further evaluated in vivo, this work emphasizes plants as potent sources of new antimicrobial agents when resistance to antibiotics increases dramatically.
American Psychological Association (APA)
Abedini, Amin& Roumy, Vincent& Mahieux, Séverine& Biabiany, Murielle& Standaert-Vitse, Annie& Rivière, Céline…[et al.]. 2013. Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae). Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-484400
Modern Language Association (MLA)
Abedini, Amin…[et al.]. Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae). Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-484400
American Medical Association (AMA)
Abedini, Amin& Roumy, Vincent& Mahieux, Séverine& Biabiany, Murielle& Standaert-Vitse, Annie& Rivière, Céline…[et al.]. Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae). Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-484400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484400