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Antithrombotic Medication for Cardioembolic Stroke Prevention
Joint Authors
Arboix, Adrià
Krupinski, Jerzy
Font, M. Àngels
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Embolism of cardiac origin accounts for about 20% of ischemic strokes.
Nonvalvular atrial fibrillation is the most frequent cause of cardioembolic stroke.
Approximately 1% of population is affected by atrial fibrillation, and its prevalence is growing with ageing in the modern world.
Strokes due to cardioembolism are in general severe and prone to early recurrence and have a higher long-term risk of recurrence and mortality.
Despite its enormous preventive potential, continuous oral anticoagulation is prescribed for less than half of patients with atrial fibrillation who have risk factors for cardioembolism and no contraindications for anticoagulation.
Available evidence does not support routine immediate anticoagulation of acute cardioembolic stroke.
Anticoagulation therapy's associated risk of hemorrhage and monitoring requirements have encouraged the investigation of alternative therapies for individuals with atrial fibrillation.
New anticoagulants being tested for prevention of stroke are low-molecular-weight heparins (LMWH), unfractionated heparin, factor Xa inhibitors, or direct thrombin inhibitors like dabigatran etexilate and rivaroxaban.
The later exhibit stable pharmacokinetics obviating the need for coagulation monitoring or dose titration, and they lack clinically significant food or drug interaction.
Moreover, they offer another potential that includes fixed dosing, oral administration, and rapid onset of action.
There are several concerns regarding potential harm, including an increased risk for hepatotoxicity, clinically significant bleeding, and acute coronary events.
Therefore, additional trials and postmarketing surveillance will be needed.
American Psychological Association (APA)
Font, M. Àngels& Krupinski, Jerzy& Arboix, Adrià. 2011. Antithrombotic Medication for Cardioembolic Stroke Prevention. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-484684
Modern Language Association (MLA)
Font, M. Àngels…[et al.]. Antithrombotic Medication for Cardioembolic Stroke Prevention. Stroke Research and Treatment No. 2011 (2011), pp.1-23.
https://search.emarefa.net/detail/BIM-484684
American Medical Association (AMA)
Font, M. Àngels& Krupinski, Jerzy& Arboix, Adrià. Antithrombotic Medication for Cardioembolic Stroke Prevention. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-484684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484684