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Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node Dissection
Joint Authors
Wawroschek, Friedhelm
Henke, Rolf-Peter
Winter, Alexander
Uphoff, Jens
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
To evaluate whether secondary resection of lymph node (LN) metastases (LNMs) can result in PSA remission, we analysed the PSA outcome after resection of LNM detected on PET/CT in patients with biochemical failure.
Materials and Methods.
11 patients with PSA relapse (mean 3.02 ng/mL, range 0.5–9.55 ng/mL) after radical prostatectomy without adjuvant therapy were included.
Suspicious LN (1–3) detected on choline PET/CT and nearby LN were openly dissected (09/04–02/11).
The PSA development was examined.
Histological and PET/CT findings were compared.
Results.
9 of 10 patients with histologically confirmed LNM showed a PSA response.
4 of 9 patients with single LNM had a complete permanent PSA remission (mean followup 31.8, range 1–48 months).
Of metastasis-suspicious LNs (14) 12 could be histologically confirmed.
The additionally removed 25 LNs were all correctly negative.
Conclusions.
The complete PSA remissions after secondary resection of single LNM argue for a feasible therapeutic benefit without adjuvant therapy.
For this purpose the choline PET/CT is in spite of its limitations currently the most reliable routinely available diagnostic tool.
American Psychological Association (APA)
Winter, Alexander& Uphoff, Jens& Henke, Rolf-Peter& Wawroschek, Friedhelm. 2011. Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node Dissection. Advances in Urology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484867
Modern Language Association (MLA)
Winter, Alexander…[et al.]. Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node Dissection. Advances in Urology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-484867
American Medical Association (AMA)
Winter, Alexander& Uphoff, Jens& Henke, Rolf-Peter& Wawroschek, Friedhelm. Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node Dissection. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484867