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Semiautomatic Segmentation of Ventilated Airspaces in Healthy and Asthmatic Subjects Using Hyperpolarized 3He MRI
Joint Authors
Lutchen, K. R.
Parameswaran, H.
LaPrad, A. S.
Lui, J. K.
Albert, M. S.
Sun, Y.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A segmentation algorithm to isolate areas of ventilation from hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI) is described.
The algorithm was tested with HP 3He MRI data from four healthy and six asthmatic subjects.
Ventilated lung volume (VLV) measured using our semiautomated technique was compared to that obtained from manual outlining of ventilated lung regions and to standard spirometric measurements.
VLVs from both approaches were highly correlated (R=0.99; P<0.0001) with a mean difference of 3.8 mL and 95% agreement indices of −30.8 mL and 38.4 mL.
There was no significant difference between the VLVs obtained through the semiautomatic approach and the manual approach.
A Dice coefficient which quantified the intersection of the two datasets was calculated and ranged from 0.95 to 0.97 with a mean of 0.96 ± 0.01 (mean ± SD).
VLVs obtained through the semiautomatic algorithm were also highly correlated with measurements of forced expiratory volume in one second (FEV1) (R=0.82; P=0.0035) and forced vital capacity (FVC) (R=0.95; P<0.0001).
The technique may open new pathways toward advancing more quantitative characterization of ventilation for routine clinical assessment for asthma severity as well as a number of other respiratory diseases.
American Psychological Association (APA)
Lui, J. K.& LaPrad, A. S.& Parameswaran, H.& Sun, Y.& Albert, M. S.& Lutchen, K. R.. 2013. Semiautomatic Segmentation of Ventilated Airspaces in Healthy and Asthmatic Subjects Using Hyperpolarized 3He MRI. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486061
Modern Language Association (MLA)
Lui, J. K.…[et al.]. Semiautomatic Segmentation of Ventilated Airspaces in Healthy and Asthmatic Subjects Using Hyperpolarized 3He MRI. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-486061
American Medical Association (AMA)
Lui, J. K.& LaPrad, A. S.& Parameswaran, H.& Sun, Y.& Albert, M. S.& Lutchen, K. R.. Semiautomatic Segmentation of Ventilated Airspaces in Healthy and Asthmatic Subjects Using Hyperpolarized 3He MRI. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486061