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Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence : A Case of the Emperor's New Clothes?
Joint Authors
Rattehalli, Ranganath D.
Jayaram, Mahesh
Adams, Clive E.
Source
Schizophrenia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Advent of “atypical” antipsychotics has spawned new trials in the recent years and the number of such trial reports has been increasing exponentially.
As clinicians we have been led to believe that “atypicals” are better than “typicals” despite the odd dissenting voice in academic and clinical circles.
This has been largely ignored until the publication of two landmark, independent, pragmatic trials, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS), which proved that thoughtfully chosen “typical” antipsychotics were as good as the newer “atypicals.” We pooled “leaving the study early data” from Cochrane Reviews that existed before CATIE and CUtLASS and added data from CATIE and CUtLASS to the pool for a “before and after” comparison.
Addition of CATIE and CUtLASS data only led to narrowing of the already existing confidence intervals, merely increasing precision, and decreasing the risk of Type II error.
Perhaps surprisingly, CATIE and CUtLASS when pooled with the already existing data showed us that we had chosen to turn a blind eye to findings that already existed.
This leads clinicians to question as to whether, in future, we need to feel less guilty about crying out early on that the emperor has no clothes on.
American Psychological Association (APA)
Jayaram, Mahesh& Rattehalli, Ranganath D.& Adams, Clive E.. 2012. Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence : A Case of the Emperor's New Clothes?. Schizophrenia Research and Treatment،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-486155
Modern Language Association (MLA)
Jayaram, Mahesh…[et al.]. Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence : A Case of the Emperor's New Clothes?. Schizophrenia Research and Treatment No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-486155
American Medical Association (AMA)
Jayaram, Mahesh& Rattehalli, Ranganath D.& Adams, Clive E.. Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence : A Case of the Emperor's New Clothes?. Schizophrenia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-486155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486155