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Response to Modified Antitubercular Drug Regime and Antiretroviral Therapy in a Case of HIV Infection with Disseminated Tuberculosis with Isoniazid Induced Toxic Epidermal Necrolysis
Joint Authors
Gupta, Bhaskar
Bhattacharjee, Prithwiraj
Swami, Abhijit
Source
Case Reports in Infectious Diseases
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Toxic epidermal necrolysis (TEN) is a potentially life-threatening disorder characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes.
Without proper management,TEN can cause sepsis leading to death of the patient.
Though TEN is commonly drug induced, Isoniazid (INH) has been uncommonly associated with TEN.
As INH is one of the first line drugs in treatment of tuberculosis, TEN induced INH needs modification of antitubercular therapy (ATT) with withdrawal of INH from the treatment regime along with other supportive treatments.
Patients with HIV infection and disseminated tuberculosis need to be urgently initiated on an effective ATT on diagnosis of tuberculosis.
However, if the patient develops potential life-threatening toxicity to first line antitubercular drugs like INH, an alternative effective ATT combination needs to be started as soon as the condition of the patient stabilizes as most of these patients present in advanced stage of HIV infection and this is to be followed by antiretroviral therapy (ART) as per guidelines.
The present case reports the effectiveness of an ATT regime comprising Rifampicin, Pyrazinamide, Ethambutol, and Levofloxacin along with ART in situations where INH cannot be given in disseminated tuberculosis in HIV patients.
American Psychological Association (APA)
Swami, Abhijit& Gupta, Bhaskar& Bhattacharjee, Prithwiraj. 2012. Response to Modified Antitubercular Drug Regime and Antiretroviral Therapy in a Case of HIV Infection with Disseminated Tuberculosis with Isoniazid Induced Toxic Epidermal Necrolysis. Case Reports in Infectious Diseases،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-486228
Modern Language Association (MLA)
Swami, Abhijit…[et al.]. Response to Modified Antitubercular Drug Regime and Antiretroviral Therapy in a Case of HIV Infection with Disseminated Tuberculosis with Isoniazid Induced Toxic Epidermal Necrolysis. Case Reports in Infectious Diseases No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-486228
American Medical Association (AMA)
Swami, Abhijit& Gupta, Bhaskar& Bhattacharjee, Prithwiraj. Response to Modified Antitubercular Drug Regime and Antiretroviral Therapy in a Case of HIV Infection with Disseminated Tuberculosis with Isoniazid Induced Toxic Epidermal Necrolysis. Case Reports in Infectious Diseases. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-486228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486228