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Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia
Joint Authors
Naghavi, Anoosh
Salimi, Saeedeh
Farajian-Mashhadi, Farzaneh
Yaghmaei, Minoo
Shahrakipour, Mahnaz
Mokhtari, Mojgan
Saravani, Mohsen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia.
Method.
This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity.
Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA).
Results.
Maternal serum leptin and adiponectin were significantly higher in PE women than controls.
Serum leptin was elevated in early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) compared to controls.
Among PE patients, serum leptin was higher in EOPE than LOPE women.
However, serum adiponectin was not different between EOPE and LOPE women.
The serum leptin was significantly higher in severe PE than mild PE.
The serum adiponectin was significantly elevated in severe PE compared to controls.
Significant positive correlation was observed between leptin and adiponectin and also between leptin and BMI in controls.
Moreover significant positive correlation was observed between adiponectin and BMI in PE patients and controls.
Conclusion.
The present study showed that serum leptin level may play a significant role as a biomarker to differentiate early and late onset PE and also its relation to BMI and severity of disease.
American Psychological Association (APA)
Salimi, Saeedeh& Farajian-Mashhadi, Farzaneh& Naghavi, Anoosh& Mokhtari, Mojgan& Shahrakipour, Mahnaz& Saravani, Mohsen…[et al.]. 2014. Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486392
Modern Language Association (MLA)
Salimi, Saeedeh…[et al.]. Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-486392
American Medical Association (AMA)
Salimi, Saeedeh& Farajian-Mashhadi, Farzaneh& Naghavi, Anoosh& Mokhtari, Mojgan& Shahrakipour, Mahnaz& Saravani, Mohsen…[et al.]. Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486392