Natural Killer Cell Regulation by MicroRNAs in Health and Disease
Joint Authors
Sullivan, Ryan P.
Leong, Jeffrey W.
Fehniger, Todd A.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Natural killer (NK) cells are innate immune lymphocytes that are critical for normal host defense against infections and mediate antitumor immune responses.
MicroRNAs (miRNAs) are a family of small, noncoding RNAs that posttranscriptionally regulate the majority of cellular processes and pathways.
Our understanding of how miRNAs regulate NK cells biology is limited, but recent studies have provided novel insight into their expression by NK cells, and how they contribute to the regulation of NK cell development, maturation, survival, and effector function.
Here, we review the expression of miRNAs by NK cells, their contribution to cell intrinsic and extrinsic control of NK cell development and effector response, and their dysregulation in NK cell malignancies.
American Psychological Association (APA)
Leong, Jeffrey W.& Sullivan, Ryan P.& Fehniger, Todd A.. 2012. Natural Killer Cell Regulation by MicroRNAs in Health and Disease. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-486734
Modern Language Association (MLA)
Leong, Jeffrey W.…[et al.]. Natural Killer Cell Regulation by MicroRNAs in Health and Disease. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-486734
American Medical Association (AMA)
Leong, Jeffrey W.& Sullivan, Ryan P.& Fehniger, Todd A.. Natural Killer Cell Regulation by MicroRNAs in Health and Disease. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-486734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486734