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Antifungal Activity of Chitosan Nanoparticles and Correlation with Their Physical Properties
Joint Authors
Ing, Ling Yien
Zin, Noraziah Mohamad
Sarwar, Atif
Katas, Haliza
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The need of natural antimicrobials is paramount to avoid harmful synthetic chemicals.
The study aimed to determine the antifungal activity of natural compound chitosan and its nanoparticles forms against Candida albicans, Fusarium solani and Aspergillus niger.
Chitosan nanoparticles were prepared from low (LMW), high molecular weight (HMW) chitosan and its derivative, trimethyl chitosan (TMC).
Particle size was increased when chitosan/TMC concentration was increased from 1 to 3 mg/mL.
Their zeta potential ranged from +22 to +55 mV.
Chitosan nanoparticles prepared from different concentrations of LMW and HMW were also found to serve a better inhibitory activity against C.
albicans (MICLMW=0.25–0.86 mg/mL and MICHMW=0.6–1.0 mg/mL) and F.
solani (MICLMW=0.86–1.2 mg/mL and MICHMW=0.5–1.2 mg/mL) compared to the solution form (MIC=3 mg/mL for both MWs and species).
This inhibitory effect was also influenced by particle size and zeta potential of chitosan nanoparticles.
Besides, Aspergillus niger was found to be resistant to chitosan nanoparticles except for nanoparticles prepared from higher concentrations of HMW.
Antifungal activity of nanoparticles prepared from TMC was negligible.
The parent compound therefore could be formulated and applied as a natural antifungal agent into nanoparticles form to enhance its antifungal activity.
American Psychological Association (APA)
Ing, Ling Yien& Zin, Noraziah Mohamad& Sarwar, Atif& Katas, Haliza. 2012. Antifungal Activity of Chitosan Nanoparticles and Correlation with Their Physical Properties. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486775
Modern Language Association (MLA)
Ing, Ling Yien…[et al.]. Antifungal Activity of Chitosan Nanoparticles and Correlation with Their Physical Properties. International Journal of Biomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-486775
American Medical Association (AMA)
Ing, Ling Yien& Zin, Noraziah Mohamad& Sarwar, Atif& Katas, Haliza. Antifungal Activity of Chitosan Nanoparticles and Correlation with Their Physical Properties. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486775