Natural Compounds as Regulators of the Cancer Cell Metabolism
Joint Authors
Cerella, Claudia
Dicato, Mario
Diederich, Marc
Radogna, Flavia
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer.
Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism.
Candidate agents should display selectivity of action towards cancer cells without side effects.
This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well.
Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential.
Many of these compounds have already been characterized for their multiple anticancer activities.
Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds.
The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways.
In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism.
American Psychological Association (APA)
Cerella, Claudia& Radogna, Flavia& Dicato, Mario& Diederich, Marc. 2013. Natural Compounds as Regulators of the Cancer Cell Metabolism. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-487333
Modern Language Association (MLA)
Cerella, Claudia…[et al.]. Natural Compounds as Regulators of the Cancer Cell Metabolism. International Journal of Cell Biology No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-487333
American Medical Association (AMA)
Cerella, Claudia& Radogna, Flavia& Dicato, Mario& Diederich, Marc. Natural Compounds as Regulators of the Cancer Cell Metabolism. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-487333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487333