Surface Modification of Gelatin Nanoparticles with Polyethylenimine as Gene Vector
Joint Authors
Wu, Meng-Chao
Huang, Yi-You
Chou, Min-Ju
Kuo, Wei-Ti
Huang, Sam Hong-Yi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
A novel carrier on balancing the transfection efficiency and minimizing cytotoxicity was designed.
Gelatin cross-linked with 1.8 kDa of PEI (GA-PEI 1.8 k) formed stable complex and resulted in high positive ζ potential (42.47 mV) and buffering effect.
These nanoparticles with N/P ratio of 30 give high transfection efficiency 2.12×104 RLU/μg protein and cell viability (86.4%).
These modified GA-PEI nanoparticles, with high transfection efficiency and low cell toxicity, can be a potential gene vector in gene therapy.
American Psychological Association (APA)
Kuo, Wei-Ti& Huang, Sam Hong-Yi& Chou, Min-Ju& Wu, Meng-Chao& Huang, Yi-You. 2011. Surface Modification of Gelatin Nanoparticles with Polyethylenimine as Gene Vector. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-487875
Modern Language Association (MLA)
Kuo, Wei-Ti…[et al.]. Surface Modification of Gelatin Nanoparticles with Polyethylenimine as Gene Vector. Journal of Nanomaterials No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-487875
American Medical Association (AMA)
Kuo, Wei-Ti& Huang, Sam Hong-Yi& Chou, Min-Ju& Wu, Meng-Chao& Huang, Yi-You. Surface Modification of Gelatin Nanoparticles with Polyethylenimine as Gene Vector. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-487875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487875
