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Mycobacterial Etiology of Pulmonary Tuberculosis and Association with HIV Infection and Multidrug Resistance in Northern Nigeria
Joint Authors
El-Kamary, Samer S.
Blattner, William
Mosunmola, Iwakun
Obasanya, Joshua
Hungerford, Laura
Brown, Clayton
Ezati, Nicholas
Tracy, Kathleen J.
Abimiku, Alash'le
Aliyu, Gambo
Source
Tuberculosis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Data on pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) complex in Nigeria are limited.
We investigated species of MTB complex in TB cases from northern Nigeria.
Methods.
New TB suspects were enrolled, screened for HIV and their sputum samples were cultured after routine microscopy.
Genotypes MTBC and MTBDRplus were used to characterize the MTB complex species and their resistance to isoniazid and rifampicin.
Results.
Of the 1,603 patients enrolled, 375 (23%) had MTB complex infection: 354 (94.4%) had Mycobacterium tuberculosis; 20 (5.3%) had Mycobacterium africanum; and one had Mycobacterium bovis (0.3%).
Cases were more likely to be male (AOR = 1.87, 95% CI : 1.42–2.46; P≤0.001), young (AOR = 2.03, 95% CI : 1.56–2.65; P≤0.001) and have HIV (AOR = 1.43, 95% CI : 1.06–1.92; P=0.032).
In 23 patients (6.1%), the mycobacterium was resistant to at least one drug, and these cases were more likely to have HIV and prior TB treatment (AOR = 3.62, 95% CI : 1.51–8.84; P=0.004; AOR : 4.43; 95% CI : 1.71–11.45 P=0.002 resp.), compared to cases without any resistance.
Conclusion.
Mycobacterium tuberculosis remained the predominant specie in TB in this setting followed by Mycobacterium africanum while Mycobacterium bovis was rare.
The association of TB drug resistance with HIV has implications for TB treatment.
American Psychological Association (APA)
Aliyu, Gambo& El-Kamary, Samer S.& Abimiku, Alash'le& Ezati, Nicholas& Mosunmola, Iwakun& Hungerford, Laura…[et al.]. 2013. Mycobacterial Etiology of Pulmonary Tuberculosis and Association with HIV Infection and Multidrug Resistance in Northern Nigeria. Tuberculosis Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-488230
Modern Language Association (MLA)
Aliyu, Gambo…[et al.]. Mycobacterial Etiology of Pulmonary Tuberculosis and Association with HIV Infection and Multidrug Resistance in Northern Nigeria. Tuberculosis Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-488230
American Medical Association (AMA)
Aliyu, Gambo& El-Kamary, Samer S.& Abimiku, Alash'le& Ezati, Nicholas& Mosunmola, Iwakun& Hungerford, Laura…[et al.]. Mycobacterial Etiology of Pulmonary Tuberculosis and Association with HIV Infection and Multidrug Resistance in Northern Nigeria. Tuberculosis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-488230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488230