Premature Coronary Artery Disease and Familial Hypercholesterolemia : Need for Early Diagnosis and Cascade Screening in the Indian Population
Joint Authors
Khan, Bobby Varkey
Verma, I. C.
Setia, N.
Arora, Anjali
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cardiovascular disease (CVD) is the leading cause of death in India, accounting for 28% of mortality.
The average age of onset of CVD is younger (below 55 years) among Indians than in other populations.
This may be due to bad lifestyle, genetic factors, or both.
Hypertension, smoking, diabetes, and physical inactivity have been identified as modifiable risk factors for heart disease.
Hypercholesterolemia is the most common and treatable cause of heart disease.
Genetic factors that lead to hypercholesterolemia have not been fully studied in India.
Familial Hypercholesterolemia results from mutations in the LDL receptor, ApoB, PCSK9, and ApoE genes.
There is an urgent need to screen subjects with premature CAD and their relatives in India for the presence of FH, identify the mutations that lead to high cholesterol, and carry out cascade screening in the at-risk relatives.
Those harbouring mutations in the above genes can be treated to lower the cholesterol levels, prevent early CVD, and avoid death.
A programme based on these lines has been initiated in Delhi.
American Psychological Association (APA)
Setia, N.& Verma, I. C.& Khan, Bobby Varkey& Arora, Anjali. 2011. Premature Coronary Artery Disease and Familial Hypercholesterolemia : Need for Early Diagnosis and Cascade Screening in the Indian Population. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-488910
Modern Language Association (MLA)
Setia, N.…[et al.]. Premature Coronary Artery Disease and Familial Hypercholesterolemia : Need for Early Diagnosis and Cascade Screening in the Indian Population. Cardiology Research and Practice No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-488910
American Medical Association (AMA)
Setia, N.& Verma, I. C.& Khan, Bobby Varkey& Arora, Anjali. Premature Coronary Artery Disease and Familial Hypercholesterolemia : Need for Early Diagnosis and Cascade Screening in the Indian Population. Cardiology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-488910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488910