New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
Joint Authors
Monaco, Maria Ludovica
Bianco, Andrea
Mazzarella, Gennaro
Daniele, Aurora
Costagliola, Ciro
Nigro, Ersilia
Palmieri, Alessia
Scudiero, Olga
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer.
Adipose tissue is an endocrine organ that produces biologically active molecules defined “adipocytokines,” protein hormones with pleiotropic functions involved in the regulation of energy metabolism as well as in appetite, insulin sensitivity, inflammation, atherosclerosis, cell proliferation, and so forth.
In obesity, fat accumulation causes dysregulation of adipokine production that strongly contributes to the onset of obesity-related diseases.
Several advances have been made in the treatment and prevention of obesity but current medical therapies are often unsuccessful even in compliant patients.
Among the adipokines, adiponectin shows protective activity in various processes such as energy metabolism, inflammation, and cell proliferation.
In this review, we will focus on the current knowledge regarding the protective properties of adiponectin and its receptors, AdipoRs (“adiponectin system”), on metabolic complications in obesity and obesity-related diseases.
Adiponectin, exhibiting antihyperglycemic, antiatherogenic, and anti-inflammatory properties, could have important clinical benefits in terms of development of therapies for the prevention and/or for the treatment of obesity and obesity-related diseases.
American Psychological Association (APA)
Nigro, Ersilia& Scudiero, Olga& Monaco, Maria Ludovica& Palmieri, Alessia& Mazzarella, Gennaro& Costagliola, Ciro…[et al.]. 2014. New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-488942
Modern Language Association (MLA)
Nigro, Ersilia…[et al.]. New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-488942
American Medical Association (AMA)
Nigro, Ersilia& Scudiero, Olga& Monaco, Maria Ludovica& Palmieri, Alessia& Mazzarella, Gennaro& Costagliola, Ciro…[et al.]. New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-488942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488942