Use of Immunohistochemistry Techniques in Patients Exposed to Sulphur Mustard Gas
Joint Authors
Bahadori, Moslem
Ghanei, Mostafa
Shamsaei, Hassan
Chilosi, Marco
Tazelaar, Henry D.
Amini Harandi, Asghar
Motiei-Langroudi, Rouzbeh
Mohammad Hosseini Akbari, Hassan
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We performed a pathologic study with further using an immunohistochemical technique (using anti-p63 and anti-CK5) on tissues obtained by open lung biopsy from 18 patients with previous exposure to sulphur mustard (SM) as case group and 8 unexposed patients (control group).
The most frequent pathologic diagnosis was constrictive bronchiolitis (44.4%), followed by respiratory (22.2%) and chronic cellular bronchiolitis (16.7%) in the case group, and hypersensitivity bronchiolitis (50%) in the control group.
The pathologic diagnoses were significantly different in the case and control groups (P=0.042).
In slides stained by anti-p63 and anti-CK5, the percent of stained cells and the mean number of epithelial cells were lower in the case group in comparison to the control group.
This difference was significant for the mean number of cells stained by anti-CK5 (P=0.042).
Furthermore, there was a significant correlation between pathologic diagnosis and total number of cells and mean number of cells stained with anti-p63 and anti-CK5 (P value = 0.002, <0.001, 0.044).
These results suggest that constrictive bronchiolitis may be the major pathologic consequence of exposure to SM.
Moreover, decrease of p63 in respiratory tissues affected by SM may suggest the lack of regenerative capacity in these patients.
American Psychological Association (APA)
Ghanei, Mostafa& Chilosi, Marco& Mohammad Hosseini Akbari, Hassan& Motiei-Langroudi, Rouzbeh& Amini Harandi, Asghar& Shamsaei, Hassan…[et al.]. 2011. Use of Immunohistochemistry Techniques in Patients Exposed to Sulphur Mustard Gas. Pathology Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-489028
Modern Language Association (MLA)
Ghanei, Mostafa…[et al.]. Use of Immunohistochemistry Techniques in Patients Exposed to Sulphur Mustard Gas. Pathology Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-489028
American Medical Association (AMA)
Ghanei, Mostafa& Chilosi, Marco& Mohammad Hosseini Akbari, Hassan& Motiei-Langroudi, Rouzbeh& Amini Harandi, Asghar& Shamsaei, Hassan…[et al.]. Use of Immunohistochemistry Techniques in Patients Exposed to Sulphur Mustard Gas. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-489028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489028