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In Vitro and In Vivo Activities of Essential Oil from the Seed of Anethum graveolens L. against Candida spp.
Joint Authors
Zeng, Jingsi
Mao, Yehong
Wang, Youwei
Tian, Jun
Zeng, Hong
Zheng, Yuechen
Ban, Xiaoquan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The essential oil produced from the seed of Anethum graveolens L.
(Umbelliferae) was tested in vitro and in vivo anti-Candida activity.
The microbroth dilution method was used in the minimal inhibitory concentration (MIC), according to M27-A3 of the guidelines of the Clinical and Laboratory Standard Institute (CLSI).
And then, efficacy evaluation of essential oil in the prophylaxis and treatment of experimental vaginal candidiasis was performed in immunosuppressed mice.
The anti-Candida activity was analyzed by microbiological and histological techniques and was compared with that of fluconazole (FCZ).
The results showed essential oil was active in vitro against all tested strains, with MICs ranging from 0.312 μL/mL (for C.
tropicalis, C.
parapsilosis, and C.
krusei) to 0.625 μL/mL (for 6 isolated C.
albicans strains).
Essential oil (2% v/v) was highly efficacious in accelerating C.
albicans 09-1555 clearance from experimentally infected mice vagina by prophylaxis and therapeutic treatments.
In both therapeutic efficacy and prophylaxis studies, the histological findings confirmed the microbiological results.
The experimental results revealed that the tested essential oil is effective against vulvovaginal candidiasis in immunosuppressed mice.
American Psychological Association (APA)
Zeng, Hong& Tian, Jun& Zheng, Yuechen& Ban, Xiaoquan& Zeng, Jingsi& Mao, Yehong…[et al.]. 2011. In Vitro and In Vivo Activities of Essential Oil from the Seed of Anethum graveolens L. against Candida spp.. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489047
Modern Language Association (MLA)
Zeng, Hong…[et al.]. In Vitro and In Vivo Activities of Essential Oil from the Seed of Anethum graveolens L. against Candida spp.. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-489047
American Medical Association (AMA)
Zeng, Hong& Tian, Jun& Zheng, Yuechen& Ban, Xiaoquan& Zeng, Jingsi& Mao, Yehong…[et al.]. In Vitro and In Vivo Activities of Essential Oil from the Seed of Anethum graveolens L. against Candida spp.. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489047