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How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer
Joint Authors
Soares, Paula
Torres, Joana
Sobrinho-Simões, Manuel
Vinagre, João
Couto, Joana P.
Prazeres, Hugo
Rodrigues, Fernando
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The significance of RET in thyroid cancer comes from solid evidence that, when inherited, an RET activating mutation primes C-cells to transform into medullary carcinomas.
Moreover, environmental exposure to radiation also induces rearranged transforming RET “isoforms” that are found in papillary thyroid cancer.
The RET gene codes for a tyrosine kinase receptor that targets a diverse set of intracellular signaling pathways.
The nature of RET point mutations predicts differences in the mechanisms by which the receptor becomes activated and correlates with different forms of clinical presentation, age of onset, and biological aggressiveness.
A number of RET-targeting Tyrosine Kinase Inhibitors (TKIs) are currently undergoing clinical trials to evaluate their effectiveness in the treatment of thyroid cancer, and it is conceivable that the RET genotype may also influence response to these compounds.
The question that now emerges is whether, in the future, the rational for treatment of refractory thyroid cancer will be based on the management of an abnormal RET signal.
In this paper we address the RET-targeting TKIs and review studies about the signaling properties of distinct RET mutants as a means to predict response and design combinatorial therapies for the soon to be available TKIs.
American Psychological Association (APA)
Prazeres, Hugo& Torres, Joana& Rodrigues, Fernando& Couto, Joana P.& Vinagre, João& Sobrinho-Simões, Manuel…[et al.]. 2011. How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-489761
Modern Language Association (MLA)
Prazeres, Hugo…[et al.]. How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer. Journal of Thyroid Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-489761
American Medical Association (AMA)
Prazeres, Hugo& Torres, Joana& Rodrigues, Fernando& Couto, Joana P.& Vinagre, João& Sobrinho-Simões, Manuel…[et al.]. How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-489761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489761