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Identification of Simple Sequence Repeat Biomarkers through Cross-Species Comparison in a Tag Cloud Representation
Joint Authors
Chang, Hao-Teng
Huang, Jhen-Li
Pai, Tun-Wen
Hsu, Hui-Huang
Cheng, Ronshan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Simple sequence repeats (SSRs) are not only applied as genetic markers in evolutionary studies but they also play an important role in gene regulatory activities.
Efficient identification of conserved and exclusive SSRs through cross-species comparison is helpful for understanding the evolutionary mechanisms and associations between specific gene groups and SSR motifs.
In this paper, we developed an online cross-species comparative system and integrated it with a tag cloud visualization technique for identifying potential SSR biomarkers within fourteen frequently used model species.
Ultraconserved or exclusive SSRs among cross-species orthologous genes could be effectively retrieved and displayed through a friendly interface design.
Four different types of testing cases were applied to demonstrate and verify the retrieved SSR biomarker candidates.
Through statistical analysis and enhanced tag cloud representation on defined functional related genes and cross-species clusters, the proposed system can correctly represent the patterns, loci, colors, and sizes of identified SSRs in accordance with gene functions, pattern qualities, and conserved characteristics among species.
American Psychological Association (APA)
Huang, Jhen-Li& Chang, Hao-Teng& Cheng, Ronshan& Hsu, Hui-Huang& Pai, Tun-Wen. 2014. Identification of Simple Sequence Repeat Biomarkers through Cross-Species Comparison in a Tag Cloud Representation. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-489814
Modern Language Association (MLA)
Huang, Jhen-Li…[et al.]. Identification of Simple Sequence Repeat Biomarkers through Cross-Species Comparison in a Tag Cloud Representation. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-489814
American Medical Association (AMA)
Huang, Jhen-Li& Chang, Hao-Teng& Cheng, Ronshan& Hsu, Hui-Huang& Pai, Tun-Wen. Identification of Simple Sequence Repeat Biomarkers through Cross-Species Comparison in a Tag Cloud Representation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-489814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489814