Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis
Joint Authors
Wong, Ester Shuk-Ying
Zhang, HuiJuan
Wong, Oscar Gee-Wan
Jiang, LiLi
Cheung, Annie Nga-Yin
Siu, Michelle Kwan-Yee
Huo, Zhen
Source
Obstetrics and Gynecology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas.
By methylation-specific polymerase chain reaction (MS-PCR), the methylation status of SOX2 promoter region in 72 endometrial carcinomas and 12 normal endometrial samples was examined.
Methylated allele was found in 37.5% (27/72) of endometrial carcinomas but only in 8.3% (1/12) of normal endometrial, significantly more frequent in cancers (P=.0472).
SOX2 mRNA level was significantly reduced in endometrial carcinoma compared with nonneoplastic endometrium (P=.045).
A significant correlation between SOX2 mRNA expression and hypermethylation of SOX2 was found (P=.024).
Hypermethylation of SOX2 tended to be more frequently found in type II serous or clear cell adenocarcinoma.
SOX2 methylation was also significantly correlated with shorter survival of patients (P=.046).
In conclusion, epigenetic mechanisms may play a crucial role on the transcriptional regulation of SOX2 and loss of SOX2 expression may be related to endometrial carcinogenesis.
American Psychological Association (APA)
Wong, Oscar Gee-Wan& Huo, Zhen& Siu, Michelle Kwan-Yee& Zhang, HuiJuan& Jiang, LiLi& Wong, Ester Shuk-Ying…[et al.]. 2010. Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-490169
Modern Language Association (MLA)
Wong, Oscar Gee-Wan…[et al.]. Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis. Obstetrics and Gynecology International No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-490169
American Medical Association (AMA)
Wong, Oscar Gee-Wan& Huo, Zhen& Siu, Michelle Kwan-Yee& Zhang, HuiJuan& Jiang, LiLi& Wong, Ester Shuk-Ying…[et al.]. Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-490169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490169