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Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae)
Joint Authors
Araújo, Tiago Gomes
Leite, Ana Catarina Rezende
Lima, Vera Lúcia de Menezes
Maia, Maria Bernadete de Sousa
Carvalho, Bruno de Melo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal and alloxan-induced diabetic rats, treated with HEPA (125 and 250 mg/kg; p.o.).
Oral glucose tolerance test, acute oral toxicity test and preliminary phytochemical analyses were performed.
The diabetic rats treated with HEPA showed a significant reduction in serum and urinary glucose, urinary urea and triglyceride levels, as compared to the diabetic untreated group.
However, in the normal treated groups, a significant reduction was found only in serum triglyceride levels.
In all treated diabetic groups, an improvement in hepatic glycogen was observed, as well as a decrease in liquid intake and urinary volume, and an enhancement in the weight of skeletal muscles (soleus and extensor digitorum longus), kidneys and epididymal adipose tissue.
Nevertheless, body and liver weights were ameliorated only in the diabetic group treated with HEPA (250 mg/kg).
Moreover, oral glucose tolerance was higher in animals treated with HEPA, while results also showed that HEPA could be considered toxicologically safe.
Phytochemical analysis revealed the presence of tanins, flavonoids and steroids in HEPA.
In conclusion, P.
aculeata presents an antidiabetic activity and other beneficial effects that ameliorate diabetes and associated complications.
American Psychological Association (APA)
Leite, Ana Catarina Rezende& Araújo, Tiago Gomes& Carvalho, Bruno de Melo& Maia, Maria Bernadete de Sousa& Lima, Vera Lúcia de Menezes. 2010. Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae). Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491000
Modern Language Association (MLA)
Leite, Ana Catarina Rezende…[et al.]. Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae). Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-491000
American Medical Association (AMA)
Leite, Ana Catarina Rezende& Araújo, Tiago Gomes& Carvalho, Bruno de Melo& Maia, Maria Bernadete de Sousa& Lima, Vera Lúcia de Menezes. Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae). Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491000