Newborn Screening for Sickle Cell Disease : Technical and Legal Aspects of a German Pilot Study with 38,220 Participants
Joint Authors
Brose, Annemarie
Frömmel, Claudia
Blankenstein, Oliver
Klein, Jeannette
Lobitz, Stephan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sickle cell disease (SCD) does not occur in the indigenous German population, but with the increasing number of immigrants from countries at high risk for hemoglobinopathies, the question emerges whether or not a newborn screening program (NBS) for SCD disease should be initiated in Germany anyhow.
We have recently shown that in Berlin, a city with a very large immigrant population, the incidence of SCD is considerable, but our findings are insufficient to make a decision for the country as a whole.
In this paper we will show that a large body of epidemiological data can be generated in a relatively short period of time, with a very high degree of precision and at relatively little expense—a result that might motivate other working groups to start such a pilot project locally.
We examined previously collected dried blood cards that were up to six months old, using high performance liquid chromatography (HPLC) as first method and capillary electrophoresis (CE) as second method.
A single, part-time laboratory technician processed 38,220 samples in a period of 162 working days.
The total costs per sample including all incidentals (as well as labor costs) were EUR 1.44.
American Psychological Association (APA)
Frömmel, Claudia& Brose, Annemarie& Klein, Jeannette& Blankenstein, Oliver& Lobitz, Stephan. 2014. Newborn Screening for Sickle Cell Disease : Technical and Legal Aspects of a German Pilot Study with 38,220 Participants. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-491303
Modern Language Association (MLA)
Frömmel, Claudia…[et al.]. Newborn Screening for Sickle Cell Disease : Technical and Legal Aspects of a German Pilot Study with 38,220 Participants. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-491303
American Medical Association (AMA)
Frömmel, Claudia& Brose, Annemarie& Klein, Jeannette& Blankenstein, Oliver& Lobitz, Stephan. Newborn Screening for Sickle Cell Disease : Technical and Legal Aspects of a German Pilot Study with 38,220 Participants. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-491303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491303