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Synthesis, Characterization and In Vitro Antibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone (H2dampt)
Joint Authors
Salam, M. A.
Ahmad, Fasihuddin Badruddin
Sam, Norrihan
Saha, Ramkrishna
Affan, M. A.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Five new organotin(IV) complexes of 2-hydroxyacetophenone-2-methylphenylthiosemicarbazone [H2dampt, (1)] with formula [RSnCln-1(dampt)] (where R=Me, n=2 (2); R=Bu, n=2 (3); R=Ph, n=2 (4); R=Me2, n=1 (5); R=Ph2, n=1 (6)) have been synthesized by direct reaction of H2dampt (1) with organotin(IV) chloride(s) in absolute methanol.
The ligand (1) and its organotin(IV) complexes (2–6) were characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, 1H, 13C, and 119Sn NMR spectral studies.
H2dampt (1) is newly synthesized and has been structurally characterized by X-ray crystallography.
Spectroscopic data suggested that H2dampt (1) is coordinated to the tin(IV) atom through the thiolate-S, azomethine-N, and phenoxide-O atoms; the coordination number of tin is five.
The in vitro antibacterial activity has been evaluated against Staphylococcus aureus, Enterobacter aerogenes, Escherichia coli, and Salmonella typhi.
The screening results have shown that the organotin(IV) complexes (2–6) have better antibacterial activities and have potential as drugs.
Furthermore, it has been shown that diphenyltin(IV) derivative (6) exhibits significantly better activity than the other organotin(IV) derivatives (2–5).
American Psychological Association (APA)
Salam, M. A.& Affan, M. A.& Saha, Ramkrishna& Ahmad, Fasihuddin Badruddin& Sam, Norrihan. 2012. Synthesis, Characterization and In Vitro Antibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone (H2dampt). Bioinorganic Chemistry and Applications،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-491542
Modern Language Association (MLA)
Salam, M. A.…[et al.]. Synthesis, Characterization and In Vitro Antibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone (H2dampt). Bioinorganic Chemistry and Applications No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-491542
American Medical Association (AMA)
Salam, M. A.& Affan, M. A.& Saha, Ramkrishna& Ahmad, Fasihuddin Badruddin& Sam, Norrihan. Synthesis, Characterization and In Vitro Antibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone (H2dampt). Bioinorganic Chemistry and Applications. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-491542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491542