Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated
Joint Authors
Vallicelli, Carlo
Cavaliere, Davide
Verdecchia, Giorgio Maria
Zuccalà, Valeria
Donato, Giuseppe
Sacco, Rosario
Romano, Roberto
Luposella, Maria
Patruno, Rosa
Sammarco, Giuseppe
Montemurro, Severino
Ranieri, Girolamo
Ammendola, Michele
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Angiogenesis is a complex process involved in both growth and progression of several human and animal tumours.
Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis.
Mast cells (MCs) can release tryptase following c-Kit receptor (c-KitR) activation.
Method.
In a series of 25 gastric cancer patients with stage T3N2-3M0 (by AJCC for Gastric Cancer 7th Edition), immunohistochemistry and image analysis methods were employed to evaluate in the tumour tissue the correlation between the number of mast cells positive to tryptase (MCPT), c-KitR expressing cells (c-KitR-EC), and microvascular density (MVD).
Results.
Data demonstrated a positive correlation between MCPT, c-KitR-EC, and MVD to each other.
In tumour tissue the mean number of MCPT was 15, the mean number of c-KitR-EC was 20, and the mean number of MVD was 20.
The Pearson test correlating MCPT and MVD, c-KitR-EC and MVD was significantly (r=0.64, P=0.001; r=0.66, P=0.041, resp.).
Conclusion.
In this pilot study, we suggest that MCPT and c-KitR-EC play a role in gastric cancer angiogenesis, so we think that several c-KitR or tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new antiangiogenetic approach.
American Psychological Association (APA)
Ammendola, Michele& Sacco, Rosario& Sammarco, Giuseppe& Donato, Giuseppe& Zuccalà, Valeria& Romano, Roberto…[et al.]. 2013. Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-491798
Modern Language Association (MLA)
Ammendola, Michele…[et al.]. Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated. Gastroenterology Research and Practice No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-491798
American Medical Association (AMA)
Ammendola, Michele& Sacco, Rosario& Sammarco, Giuseppe& Donato, Giuseppe& Zuccalà, Valeria& Romano, Roberto…[et al.]. Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-491798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491798